Since the days of Patanjali, yoga-psychology has been a favorite discipline of study. However, the complexities of modern world have had a toll on human mind. Stress is a common phenomenon. Gap between thoughts,words and actions has brought an onslaught of complexes and psycho-pathologies. Here, we can explore & discuss spiritual and yogic approaches to psycho-therapy. RRY (Ra’ja’dhira’ja Yoga) is the science of mental or psychic metamorphosis from crude to subtle mind to causal mind until merger in A'tman. It is an introversal science and requires experimentation in the inner mental laboratory.We can also initiate a discussion on the significance and use of synthesis in spiritual-oriented personal development work and bio-psychotherapy, with reference to the ground-breaking science of mano-vijinana (mindology- a science of psychic metamorphosis) of Shrii Shrii Anandamurti.